16 down
Always
set
off,
at
any
rate
(9)
Always set off, at any rate (9)
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The definition is at the end of the clue.
How the clue works
Here the definition is at any rate, and the rest is a straight anagram. Take the letters of "Always set", let "off" tell you to shuffle them, and they rearrange into the answer, which means "at least".