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Ever
supreme,
furiously
led
with
ambition
(11)
Ever supreme, furiously led with ambition (11)
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The definition is at the beginning of the clue.
How the clue works
See ever supreme sitting there at the start — that's your definition, meaning unconquerable. Then "furiously" is doing the anagram work, telling you to shuffle up the letters of "led" and "ambition" together, and out pops INDOMITABLE.