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Dregs
of
society
of
no
significance
according
to
Spooner:
twerp!
(9)
Dregs of society of no significance according to Spooner: twerp! (9)
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The definition is at the end of the clue.
How the clue works
Look at twerp at the end — that's your definition, meaning a fool. The rest is a Spoonerism, so take 'scum' (dregs of society) and 'null' (of no significance) and swap their starting sounds, which gives you 'num skull', and that sounds just like the answer.