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Tight
biceps
after
lifting
(4)
Tight biceps after lifting (4)
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The definition is at the beginning of the clue.
How the clue works
Fancy a pint while we crack this one — Tight is your definition there, meaning snug or close-fitting. Now, GUNS is slang for biceps, and "after lifting" tells you to flip it round, so GUNS reversed gives you the answer.