5 down
Amoebae
and
such
travelled
nautical
miles,
giving
up
sex
in
retrospect
(11)
Amoebae and such travelled nautical miles, giving up sex in retrospect (11)
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The definition is at the beginning of the clue.
How the clue works
Amoebae and such is the definition, pointing to this archaic word for microscopic organisms. Take the letters of "nautical miles" and remove "it" (a euphemism for sex, here read backwards from "in retrospect"), then "travelled" tells you to anagram what's left to spell ANIMALCULES.