26 across
Make
a
mess
of
motorway
gradient
(6)
Make a mess of motorway gradient (6)
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The definition is at the beginning of the clue.
How the clue works
Right, so Make a mess of is your definition — to mangle or damage something. For the wordplay, stick M (the usual abbreviation for motorway) in front of ANGLE, which is your gradient or slope, and that gives you the answer.