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Insults
marrow
in
seconds
(5)
Insults marrow in seconds (5)
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The definition is at the beginning of the clue.
How the clue works
Insults is your definition there, matching "snub" or slight someone. For the wordplay, take NUB (marrow, as in the core or essence of something) and slot it inside SS, which gives you two seconds — pop them together and you've got your answer.