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Not
much
of
an
experience
for
the
Artemis
II
crew
at
the
end
(1,4,2,3,5)
Not much of an experience for the Artemis II crew at the end (1,4,2,3,5)
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The whole clue is the definition (& lit or double definition).
How the clue works
This is a double definition: Not much is the idiomatic meaning of A DROP IN THE OCEAN (a tiny, insignificant amount). The second half, an experience for the Artemis II crew at the end, whimsically describes their mission's finale — literally a drop into the ocean at splashdown.