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Chemist
replacing
parts
of
large
Whopper
(6)
Chemist replacing parts of large Whopper (6)
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The definition is at the beginning of the clue.
How the clue works
The definition is Chemist, referring to Justus von Liebig. "Large" gives BIG and "Whopper" gives LIE (a whopper is a big lie), and "replacing parts" tells you to swap their order, producing LIE + BIG = LIEBIG.