23 down
Tibetan
priest
leaves
US
city
for
instrument
(5)
Tibetan priest leaves US city for instrument (5)
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The definition is at the end of the clue.
How the clue works
Right, so instrument at the end is what we're after – the musical toy KAZOO. Now think of the US city KALAMAZOO, and pull out LAMA (that's your Tibetan priest) from inside it – whatever's left over spells out KAZOO nicely.