16 across
Man
seeks
new
drug
to
hold
water
(4,5)
Man seeks new drug to hold water (4,5)
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The definition is at the end of the clue.
How the clue works
Right, "to hold water" is your definition there, meaning something that's logical or valid. For the wordplay, "new" tells you it's an anagram — so take the letters of "Man seeks" and chuck in E (that's your drug, ecstasy), give it all a shuffle, and out pops MAKE SENSE.