13 across
Woe
is
me!
Reckless
and
extremely
risky
(6)
Woe is me! Reckless and extremely risky (6)
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hints
The definition is at the beginning of the clue.
How the clue works
"Woe is your definition here, pointing straight to misery. For the wordplay, "Reckless" tells you to anagram "is me", giving MISE, then you just need the extreme (outermost) letters of "risky" - R and Y - tacked on the end to complete MISERY.