1 across
Before
5050,
space
explorers
ultimately
pay
through
the
nose
(7)
Before 5050, space explorers ultimately pay through the nose (7)
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The definition is at the end of the clue.
How the clue works
The definition is through the nose, which is what NASALLY means. NASA (space explorers) is placed before LL (5050 in Roman numerals, L being 50) and followed by Y (the last letter, 'ultimately', of 'pay'), giving NASA+LL+Y.