2 down
Beneficial
to
add
oxygen
to
blend
(2,3)
Beneficial to add oxygen to blend (2,3)
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The definition is at the beginning of the clue.
How the clue works
Right, so Beneficial is your definition there, meaning something's helpful or useful. For the wordplay, take O, the chemical symbol for oxygen, and stick it in front of FUSE (that's your "blend"), giving you OFUSE — then just respace that as OF USE.