28 across
In
bed,
weary,
drinking
wine
–
quite
the
opposite
(7)
In bed, weary, drinking wine – quite the opposite (7)
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The definition is at the beginning of the clue.
How the clue works
In bed is the definition, giving RETIRED. The wordplay uses RED for wine and TIRE for weary, and although the surface reads as "weary drinking wine" (TIRE around RED), the phrase "quite the opposite" tells you to flip it so that RED wraps around TIRE, giving RE-TIRE-D.