22 down
Ralph
snatches
‘er
wig
(6)
Ralph snatches ‘er wig (6)
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The definition is at the end of the clue.
How the clue works
Right, so wig is your definition — PERUKE's an old-fashioned word for one. Now, "Ralph" is slang for being sick, giving you PUKE, and that word "snatches", meaning it swallows, 'ER (as in ER, the pronoun) — so you split PUKE apart and drop ER right into the middle, giving P-ER-UKE.