21 across
Organisation
is
the
essence
of
paradox,
famously
(5)
Organisation is the essence of paradox, famously (5)
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The definition is at the beginning of the clue.
How the clue works
Right, so Organisation is your definition here — pointing to the charity Oxfam. Now look inside "paradOX FAMously" — "essence of" tells you the answer's hiding right there in the middle of the phrase, letters sitting consecutively across the words.