5 down
Female
serving
as
half
of
ward
sister’s
replacement
(8)
Female serving as half of ward sister’s replacement (8)
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The definition is at the beginning of the clue.
How the clue works
The answer is a Female serving in a restaurant. Take "wa" from the first half of "ward", add "sister", then let "replacement" tell you to rearrange those letters (WA plus SISTER) to spell WAITRESS.