5 down
Female
serving
as
half
of
ward
sister’s
replacement
(8)
Female serving as half of ward sister’s replacement (8)
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The definition is at the beginning of the clue.
How the clue works
Right, so Female serving is your definition there - that's a waitress. For the wordplay, take the first half of "ward", giving you WA, then stick on an anagram of SISTER (that's your "replacement" doing the anagram work) which rearranges to ITRESS - jam them together and you've got the answer.