27 across
Big
noise
in
family
group
estranging
nearly
all?
(5)
Big noise in family group estranging nearly all? (5)
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The definition is at the beginning of the clue.
How the clue works
The definition here is Big noise, which a CLANG certainly is. Take CLAN for a family group, then add G, which is what's left of GROUP after "estranging nearly all" its letters, and you've built CLANG.