28 across
Drunk
dwelt
on
disappointment
(3-4)
Drunk dwelt on disappointment (3-4)
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The definition is at the end of the clue.
How the clue works
Right, "disappointment" at the end is the definition, that's your let-down. Then "Drunk" is doing the work as the anagram indicator, telling you to scramble up the letters of "dwelt on" to land on LET-DOWN.