12 across
Hair
loss
ultimately
comes
before
anxiety
(6)
Hair loss ultimately comes before anxiety (6)
hints
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hints
The definition is at the end of the clue.
How the clue works
Right, so anxiety is your definition there, pointing to STRESS. For the wordplay, grab the last letter of "loss" - that's an S - and stick it in front of TRESS, which is just a lock of hair; S before TRESS gives you the answer.