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Synonyms
to
begin
with:
fly,
go
off,
make
a
run
for
it
(9)
Synonyms to begin with: fly, go off, make a run for it (9)
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The definition is at the end of the clue.
How the clue works
The definition here is make a run for it, meaning to flee. Build it up in pieces: take the first letter of "Synonyms" ("to begin with" signals S), add KED which is a type of fly, then ADDLE meaning to go off or spoil. Run them together and you get SKEDADDLE.