20 across
US
comedian
put
away
for
drugs
in
decline
(10)
US comedian put away for drugs in decline (10)
hints
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The definition is at the end of the clue.
How the clue works
The decline here is DEGENERATE, built from the US comedian Ellen DeGeneres. Take DEGENERES and swap out the ES (a nod to the drug ecstasy) for ATE, which is "put away" as in eaten, leaving DEGENERATE.