22 across
Go
round
church
for
a
sign
from
heaven
(6)
Go round church for a sign from heaven (6)
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The definition is at the end of the clue.
How the clue works
The definition is a sign from heaven, referring to the zodiac sign Pisces. PISS (meaning "go", as in urinate) is placed round CE (abbreviation for church), giving PIS-CE-S = PISCES.