22 across
Volume
in
English
about
an
isolated
regime
(10)
Volume in English about an isolated regime (10)
hints
0
checks
0
hints
The definition is at the end of the clue.
How the clue works
The isolated regime here is built from QUART (a volume) plus IN (in) plus E (abbreviation for English), giving QUARTINE, with AN tucked inside as signalled by "about an". Dropping AN into QUARTINE gives QUAR-AN-TINE, our answer.