18 across
Like
life
as
simple
as
possible?
I’ll
run
a
clue
that’s
convoluted
(11)
Like life as simple as possible? I’ll run a clue that’s convoluted (11)
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The definition is at the beginning of the clue.
How the clue works
Like life as simple as possible? is your definition — a nod to single-celled organisms. Then "convoluted" is your anagram indicator, telling you to rearrange the letters of I'll run a clue to get your answer.