18 across
Like
life
as
simple
as
possible?
I’ll
run
a
clue
that’s
convoluted
(11)
Like life as simple as possible? I’ll run a clue that’s convoluted (11)
hints
0
checks
0
hints
The definition is at the beginning of the clue.
How the clue works
Like life as simple as possible? is the definition, since a unicellular organism is the simplest single-celled form of life. The fodder "I'll run a clue" gives the letters ILLRUNACLUE, which when jumbled up as signalled by "convoluted" rearrange perfectly into UNICELLULAR.