16 across
Irritable
and
hot
in
Windy
City
(5)
Irritable and hot in Windy City (5)
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The definition is at the beginning of the clue.
How the clue works
Look at Irritable — that's your definition. Now, H is the standard abbreviation for "hot", and you chuck it in with the letters of "City", giving you CITYH. Then "Windy" is your anagram indicator, telling you to jumble H and City together to get ITCHY.