15 down
Chance
gone,
lots
being
wasted?
(6,3)
Chance gone, lots being wasted? (6,3)
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The definition is at the beginning of the clue.
How the clue works
The definition is Chance gone, meaning a wager that has failed — a losing bet. The letters of "lots being" are rearranged (signalled by "wasted") to spell LOSING BET.