4 across
Main
house
where
one
might
get
depressed
(6)
Main house where one might get depressed (6)
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The definition is at the end of the clue.
How the clue works
Where one might get depressed is your definition — a keypad being somewhere you press (depress) keys. Then it's a charade: KEY meaning main or principal, followed by PAD as an informal word for a house or dwelling.