16 across
Enjoyment’s
over
–
ready
to
leave
for
good
(5,2)
Enjoyment’s over – ready to leave for good (5,2)
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The definition is at the end of the clue.
How the clue works
Look at to leave for good — that's your definition, a euphemism for dying. Enjoyment's gives you FUN'S, which gets reversed because of over, landing you on SNUF. Then ready gives you FIT, and you put the two together to get SNUFF IT.