13 across
What
could
make
ladettes
be
loathsome
(10)
What could make ladettes be loathsome (10)
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The definition is at the end of the clue.
How the clue works
Loathsome is your definition. Then "what could make" is flagging an anagram, and the letters in ladettes be are the ones to shuffle around — rearrange them and they give you your answer neatly.