26 across
Defence
is
useless
to
hold
back
this
woman
(5)
Defence is useless to hold back this woman (5)
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The definition is at the end of the clue.
How the clue works
Look at this woman as your definition — Susie being a woman's name. Now scan inside "defencE IS USeless" and you'll spot the letters of the answer hidden in there, but you need to read them backwards, which is what "hold back" is nudging you to do.