25 across
Terribly
fat
York
bachelor
the
source
of
hot
stuff
(3,4,2,1,5)
Terribly fat York bachelor the source of hot stuff (3,4,2,1,5)
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The definition is at the end of the clue.
How the clue works
The source of hot stuff is your definition — that's the back of a lorry, the supposed origin of knocked-off ('hot') goods. Then terribly is your anagram indicator, and the letters of fat York bachelor — all fifteen of them — get thoroughly scrambled to give you the answer.