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Block
essentially
tackled
by
drain
cleaner
(4)
Block essentially tackled by drain cleaner (4)
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The definition is at the end of the clue.
How the clue works
Look at cleaner at the end — that's your definition, since soap is used for cleaning. "Block essentially" gives you O, the central letter of "block", and that gets tackled by (tucked inside) SAP, meaning drain, to give you S-O-AP.