21 across
Frenchman
retired
after
shake
with
artificial
milk
(8)
Frenchman retired after shake with artificial milk (8)
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The definition is at the end of the clue.
How the clue works
Look at artificial milk — that's your definition, a non-dairy coffee whitener. You take WITH and anagram it ("shake") to get WHIT, then RENE (a Frenchman) gets reversed ("retired") to give ENER, and that goes after to give you the whole thing.