24 across
Anticipation’s
useless
except
with
name-dropping
former
First
Lady
(10)
Anticipation’s useless except with name-dropping former First Lady (10)
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The definition is at the beginning of the clue.
How the clue works
Look at Anticipation — that's your definition, with the apostrophe-s acting as a link word meaning "is." "Useless" signals an anagram of except, giving you EXPECT, and then former First Lady is NANCY — but "name-dropping" means you lose the N, leaving ANCY. Put EXPECT and ANCY together and you're done.