4 down
Skin
rash
oddly
deep,
I’m
starting
to
itch,
unfortunately
(9)
Skin rash oddly deep, I’m starting to itch, unfortunately (9)
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The definition is at the beginning of the clue.
How the clue works
The definition is Skin, the outer layer of the body. For the wordplay, take the odd letters of rash (that's R and S), then add deep I'm plus the starting letter of itch (so, I), and you've got DEEPIMRSI — anagram that lot, with unfortunately doing the anagram signalling, and out comes your answer.