14 across
Outlaw
the
Y-chromosome?
(10)
Outlaw the Y-chromosome? (10)
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The definition is at the beginning of the clue.
How the clue works
The definition is Outlaw — a wrongdoer, or MALEFACTOR. Then the Y-chromosome? works as a cryptic second definition, since the Y-chromosome is literally the 'male factor' in genetics. Both halves are pointing at the same answer, making this a double definition.