12 across
Dislike
of
despicable
supervillain
leads
to
dangerous
game
ending
(6)
Dislike of despicable supervillain leads to dangerous game ending (6)
hints
0
checks
0
hints
The definition is at the beginning of the clue.
How the clue works
Dislike is your definition — a grudge being that lingering resentment you nurse. Despicable supervillain gives you GRU (from *Despicable Me*), and then you take the leads from dangerous game ending — D, G, E — and tack them on after to get GRU + DGE.