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Lisper
heard
to
struggle
with
start
of
Med
island,
so
weedy
(7)
Lisper heard to struggle with start of Med island, so weedy (7)
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The definition is at the end of the clue.
How the clue works
A homophone clue with a twist — the speaker has a lisp, so when they try to say Med island Sicily, their tongue-tied attempt comes out sounding like THISTLY, meaning weedy. The 'struggle' nicely evokes the lisper wrestling with all those S sounds.