24 down
Shed
Seven
essentially
leaving
the
Eastern
Mediterranean
with
nothing
(4-2)
Shed Seven essentially leaving the Eastern Mediterranean with nothing (4-2)
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The definition is at the beginning of the clue.
How the clue works
The definition is Shed — a lean-to being a simple shelter. Take LEVANT (the Eastern Mediterranean) and add O (nothing) to get LEVANTO, then "essentially" pull out the middle letter of Seven, which is V, and what you're left with is your answer.