21 down
Slight
temperature
dropping
off
with
cool
hormone
(7)
Slight temperature dropping off with cool hormone (7)
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The definition is at the end of the clue.
How the clue works
Look at hormone at the end — that's what you're after. Take INSULT (a slight), drop the T (temperature dropping off), and you're left with INSUL. Then tack on IN (cool, as in fashionable) and there's your answer.