22 down
Lacking
vigour
in
harem
is
shameful
(6)
Lacking vigour in harem is shameful (6)
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The definition is at the beginning of the clue.
How the clue works
Look at Lacking vigour — that's your definition, pointing to something negligent or careless. The sneaky bit is that "in" signals a hidden word, and if you peer inside "haREMISShameful", it's sitting right there in plain sight.