19 down
Familiar
with
your
sib’s
butt
trouble
(7)
Familiar with your sib’s butt trouble (7)
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The definition is at the end of the clue.
How the clue works
Look at trouble at the end — that's your definition, as in to disturb or unsettle. Then it's built up in pieces: PERT meaning familiar or cheeky, followed by UR as text-speak for "your", and finally B, the "butt" (last letter) of sib.