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Male
occupying
home,
troublemaker
who
should
not
be
let
loose?
(6)
Male occupying home, troublemaker who should not be let loose? (6)
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The definition is at the end of the clue.
How the clue works
Look at who should not be let loose? — that's your definition, a roundabout way of describing a prisoner. M (male) is slotted inside IN (home) and ATE (the Greek goddess of mischief, your troublemaker), giving you IN-M-ATE.