22 down
Chance
to
win
big
wasted,
lead
blown
(5)
Chance to win big wasted, lead blown (5)
hints
0
checks
0
hints
The definition is at the beginning of the clue.
How the clue works
Chance to win big is your definition — the lottery game with the big jackpot. For the wordplay, take blotto (meaning "wasted", as in absolutely plastered) and blow the lead letter, knocking off the B, and you're left with your answer.