12 across
Vicious
swine
sent
back
in
time
machine
(6)
Vicious swine sent back in time machine (6)
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The definition is at the end of the clue.
How the clue works
Look at time machine — that's your definition, the Doctor's famous vessel. Swine gives you RAT, and vicious points to SID (as in Sid Vicious), so put them together as RAT+SID and then sent back tells you to reverse the whole lot.