19 down
Go
mad
with
stress
–
most
off-putting
(8)
Go mad with stress – most off-putting (8)
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The definition is at the end of the clue.
How the clue works
Look at most off-putting at the end — that's your definition, meaning most disgusting or repulsive. "Mad" is your anagram indicator, and it's telling you to jumble up GO and STRESS together to get your answer.