25 across
Females
take
drugs
orally
(4)
Females take drugs orally (4)
hints
0
checks
0
hints
The definition is at the beginning of the clue.
How the clue works
Females gives us the answer — EWES are female sheep. The wordplay is a homophone indicated by "orally": EWES sounds like "use", meaning to take drugs (as in drug use).