12 across
Two-times
quiet
husband
one
defames
first
off
(10)
Two-times quiet husband one defames first off (10)
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The definition is at the beginning of the clue.
How the clue works
The definition is Two-times — as in cheats on a partner. You build the answer as a charade: quiet gives you P, husband gives H, one gives I, and then defames is SLANDERS, but with its first letter lopped off, leaving LANDERS.